Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases
are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower
abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive
bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence.
Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division
and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different
environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional
processes based on structural data.
Keywords: Cell division, structure, phosphorylation, peptidoglycan, Bacterial Cell Division, STPKs, KINASE DOMAIN, PASTA, MviN, EXTRACELLULAR REGION
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Published on: 10 January, 2013
Page: [756 - 766]