Title:Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications
VOLUME: 13 ISSUE: 8
Author(s):Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska, Anne-Sophie Delattre and Rob Lavigne
Affiliation:Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland.
Keywords:antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Abstract:The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic
problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant.
In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative
or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages
and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as
mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and
phage-encoded proteins application.
