Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

Author(s): Ravindra M. Kumbhare, K. Vijay Kumar, Tulshiram L. Dadmal, Umesh B. Kosurkar, K. Appalanaidu

Journal Name: Medicinal Chemistry

Volume 9 , Issue 2 , 2013

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Abstract:

A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gramnegative bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized compounds were established by elemental analysis and spectral data.

Keywords: Ethanamine derivatives, Tryptamine, Thiourea, 2-Bromoacetophenone, Antibacterial, Antifungal

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2013
Page: [287 - 293]
Pages: 7
DOI: 10.2174/1573406411309020011
Price: $65

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