A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were
synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone.
All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gramnegative
bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized
compounds were established by elemental analysis and spectral data.
Keywords: Ethanamine derivatives, Tryptamine, Thiourea, 2-Bromoacetophenone, Antibacterial, Antifungal
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Published on: 09 January, 2013
Page: [287 - 293]