Title:Synthesis of 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2- a] pyrimidin-4-one Derivatives as Antibacterial Agents
VOLUME: 9 ISSUE: 2
Author(s):Byregowda Krishnamurthy, Kambappa Vinaya, Devraj Rakshith, Doddakunche Shivaramu Prasanna and Kanchugarakoppal Subbegowda Rangappa
Affiliation:Department of Studies in Chemistry, University of Mysore Manasagangotri Mysore-570006, India.
Keywords:2-Aminopyridine, Antibacterial activity, Aromatic amines, Phosphorousoxychloride, Reduction, Strepyomycin
Abstract:A series of novel 3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one aliphatic/
aromatic/ heterocyclic amine derivatives were synthesized in good yield. The synthesized compounds were characterized
by 1H-NMR, FTIR and elemental analysis. All the synthesized compounds were screened for their in vitro antibacterial
activity by agar well diffusion and micro dilution method against standard strains of Gram-Positive (Bacillus Subtilis
MTCC 121 and Staphylococcus epidermidis 435), and Gram-negative (Xanthomonas Campestris 7903 and Pseudomonas
aeruginosa MTCC 7908) bacteria. Compounds with substituted heterocyclic piperazine moiety showed good activity. In
particular, compound 6i showed two fold better activity compared to the standard drug Strepyomycin sulphate.
