Kinases have been known as important molecular targets for various diseases and p38 kinase is found to be vital
target among all mitogen activated protein kinases for inflammatory diseases. P38 kinase inhibitors bearing urea scaffold
have shown potent kinase inhibitory activity and also selectivity over other kinases. We present here the synthesis,
p38 kinase inhibitory and anti-inflammatory activities of compounds containing N', N"-diarylurea scaffold. Compound 7f
demonstrated IC50 value of 1.09 μM in p38 kinase assay and 79.41% inhibition of rat paw edema at the 2nd hour of carrageenan
challenge. The molecular docking studies of synthesized compounds indicated some of the important hydrogen
bonding interactions and also revealed the minor change in the binding pose when compared to BIRB796.