A QSAR Study on Some Series of Anticancer Tyrosine Kinase Inhibitors

Author(s): Zaihra Anwer, Satya P. Gupta

Journal Name: Medicinal Chemistry

Volume 9 , Issue 2 , 2013

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Abstract:

A quantitative structure-activity relationship (QSAR) study has been made on two different series of anticancer tyrosine kinase inhibitors, namely a series of 4-alkynyl and 4-alkenyl-quinazolines and a series of N-4,6-pyrimidine-Nalkyl- N'-phenyl ureas. For the first series, QSAR results indicate that the activity is controlled by the hydrophobicity of the molecules and molecular connectivity index of the substituent, whereas for the second series of compounds the activity is found to be controlled by the molecular connectivity index of the substituent and some indicator variables.

Keywords: Quantitative structure-activity relationship, Tyrosine kinase inhibitors, Lck inhibitors, Endothelial growth factor receptor (EGFR), 4-alkynylquinazolines, 4-alkenylquinazolines, N-4, 6-pyrimidine-N-alkyl-N’-phenyl ureas.

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2013
Page: [203 - 212]
Pages: 10
DOI: 10.2174/1573406411309020005
Price: $65

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