Functional Magnetic Resonance Imaging (FMRI) is a non-invasive technique for brain mapping and mostly performed using
changes of the blood-oxygen-level-dependent (BOLD)–signal. It has been widely used to investigate patients with schizophrenia. Most of
the studies examine patients treated with antipsychotic drugs, although little is known about the effects of these drugs on the BOLDsignal.
Here we examined studies of patients with schizophrenia treated with different antipsychotics to address the question whether and
to what extent antipsychotic drugs in themselves produce BOLD-signal changes. We performed a PubMed-search for the period from
1999 until January 2012 with the search items “schizophrenia” and “Magnetic Resonance Imaging” and “Antipsychotic Agents; or
“Magnetic Resonance Imaging” and “Antipsychotic Agents”; or “schizophrenia” and “Antipsychotic Agents” and “FMRI”. We extracted
articles that examined at least two patient groups with different treatments, or patients examined on different medications at different
times and that provided information about drug effects. No common effect of antipsychotics on BOLD-signal was found. However, based
on the results for different antipsychotics (haloperidol, olanzapine, quetiapine and risperidone) we found evidence that the affinity to the
dopamine (DA) D2-receptor may influence BOLD-signal.
Keywords: Schizophrenia, FMRI, antipsychotics, BOLD, review, dopamine receptor
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