Advances in Organic Synthesis

Volume: 4

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...
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Synthesis of Trifluoromethyl-Substituted Fused Bicyclic Heterocycles and their Corresponding Benzo-Fused Analogues

Pp. 409-455 (47)

Ahmed H. M. Elwahy and Mohamed R. Shaaban


Development of efficient routes to many kinds of fluorine-containing heterocycles is an attractive area of research since these compounds are now widely recognized as important organic materials for their potential use in medicinal and agricultural scientific fields. This review survey research works on trifluoromethylsubstituted fused bicyclic heterocycles and their corresponding benzo-fused analogues over the last twelve years. Different approaches for the synthesis of such systems are discussed.


Organofluorine, trifluoromethyl, bicyclic fused heterocycles, fused pyrroles, fused thiadiazoles, fused pyrazines, fused phthalazines, fused pyridines, fused pyrimidines, fused pyridazines, fused triazines, fused tetrazines, fused benzimidazoles, fused triazoles, fused pyrazoles, fused isoxazoles, fused pyrans, fused chromenes, fused naphthyridines, fused diazepines.


Department of Chemistry, Cairo university, Giza, Egypt