Three-Component Green Reaction of Arylaldehydes, 6-Amino-1,3- Dimethyluracil and Active Methylene Compounds Catalyzed by Zr(HSO4)4 Under Solvent-Free Conditions

Author(s): Shahrzad Abdolmohammadi, Saeed Balalaie, Mohammad Barari, Frank Rominger

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 2 , 2013

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A convenient one-pot, three-component reaction of aromatic aldehydes, 6-amino-1,3-dimethyluracil and active methylene compounds in the presence of Zr(HSO4)4 as a heterogeneous catalyst, under solvent-free conditions brings a very simple and highly efficient method for the preparation of pyrimido[4,5-b]quinolines, pyrimido[5',4':5,6]pyrido[2,3- d]pyrimidines, indeno[2',1':5,6]pyrido[2,3-d]pyrimidines and a new class of pyrimidinedione derivatives in excellent yields. This approach is general and provides several advantages such as simple reaction set-up, very mild reaction conditions, high yields, recyclability of the catalyst and environmentally friendly benign.

Keywords: 6-Amino-1, 3-dimethyluracil, Solvent-free, Tandem Knoevenagel-Michael addition, Zr(HSO4)4.

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Article Details

Year: 2013
Published on: 03 January, 2013
Page: [150 - 159]
Pages: 10
DOI: 10.2174/1386207311316020009
Price: $65

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