Three-Component Green Reaction of Arylaldehydes, 6-Amino-1,3- Dimethyluracil and Active Methylene Compounds Catalyzed by Zr(HSO4)4 Under Solvent-Free Conditions

Title:Three-Component Green Reaction of Arylaldehydes, 6-Amino-1,3- Dimethyluracil and Active Methylene Compounds Catalyzed by Zr(HSO4)4 Under Solvent-Free Conditions

Volume: 16 Issue: 2

Author(s): Shahrzad Abdolmohammadi, Saeed Balalaie, Mohammad Barari and Frank Rominger

Affiliation:

Keywords: 6-Amino-1, 3-dimethyluracil, Solvent-free, Tandem Knoevenagel-Michael addition, Zr(HSO4)4.

Abstract: A convenient one-pot, three-component reaction of aromatic aldehydes, 6-amino-1,3-dimethyluracil and active methylene compounds in the presence of Zr(HSO4)4 as a heterogeneous catalyst, under solvent-free conditions brings a very simple and highly efficient method for the preparation of pyrimido[4,5-b]quinolines, pyrimido[5',4':5,6]pyrido[2,3- d]pyrimidines, indeno[2',1':5,6]pyrido[2,3-d]pyrimidines and a new class of pyrimidinedione derivatives in excellent yields. This approach is general and provides several advantages such as simple reaction set-up, very mild reaction conditions, high yields, recyclability of the catalyst and environmentally friendly benign.

Cite this article as:

Abdolmohammadi Shahrzad, Balalaie Saeed, Barari Mohammad and Rominger Frank, Three-Component Green Reaction of Arylaldehydes, 6-Amino-1,3- Dimethyluracil and Active Methylene Compounds Catalyzed by Zr(HSO4)4 Under Solvent-Free Conditions, Combinatorial Chemistry & High Throughput Screening 2013; 16 (2) . https://dx.doi.org/10.2174/1386207311316020009