Abstract
The catalytic property of Cu(II) Schiff-base complex in an efficient synthesis of 1,8-dioxodecahydroacridines was investigated. The one-pot three component reaction of dimedone, aromatic aldehydes and aromatic amines or ammonium acetate in water afforded the corresponding 1,8-dioxodecahydroacridines with excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts at room temperature. The reusability of the catalysts was demonstrated by a five-run test without loss of its activity. Also, this catalyst possesses several advantages including mild reaction conditions, lower catalytic loading, shorter reaction times, high yield of the products, inexpensive and cleaner (Green chemistry) reactions.
Keywords: 1, 8-Dioxodecahydroacridine, Cu(II) Schiff-base catalyst, multi component reaction, one-pot synthesis, water solvent, water, Green chemistry, Acridine, green catalysts, polar solvents.
Combinatorial Chemistry & High Throughput Screening
Title:Cu(II) Schiff Base as Catalyst in the Synthesis of 1,8-Dioxodecahydroacridine
Volume: 16 Issue: 1
Author(s): Seyed Mohammad Vahdat, Hamid Reza Mardani, Hamid Golchoubian, Maryam Khavarpour, Saeed Baghery and Ziba Roshankouhi
Affiliation:
Keywords: 1, 8-Dioxodecahydroacridine, Cu(II) Schiff-base catalyst, multi component reaction, one-pot synthesis, water solvent, water, Green chemistry, Acridine, green catalysts, polar solvents.
Abstract: The catalytic property of Cu(II) Schiff-base complex in an efficient synthesis of 1,8-dioxodecahydroacridines was investigated. The one-pot three component reaction of dimedone, aromatic aldehydes and aromatic amines or ammonium acetate in water afforded the corresponding 1,8-dioxodecahydroacridines with excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts at room temperature. The reusability of the catalysts was demonstrated by a five-run test without loss of its activity. Also, this catalyst possesses several advantages including mild reaction conditions, lower catalytic loading, shorter reaction times, high yield of the products, inexpensive and cleaner (Green chemistry) reactions.
Export Options
About this article
Cite this article as:
Vahdat Mohammad Seyed, Mardani Reza Hamid, Golchoubian Hamid, Khavarpour Maryam, Baghery Saeed and Roshankouhi Ziba, Cu(II) Schiff Base as Catalyst in the Synthesis of 1,8-Dioxodecahydroacridine, Combinatorial Chemistry & High Throughput Screening 2013; 16 (1) . https://dx.doi.org/10.2174/1386207311316010002
DOI https://dx.doi.org/10.2174/1386207311316010002 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
Call for Papers in Thematic Issues
Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems
Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more
Eco-friendly Agents for Biological Control of Pathogenic Diseases
The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more
Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders
Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more
Exploring Spectral Graph Theory in Combinatorial Chemistry
Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cell-based Therapy for Hypertension: Challenges and Perspectives
Current Pharmaceutical Design Editorial (Oxidative Stress in the Vascular Wall: A Useful Physiological Process or a Therapeutic Target in Vascular Disease?)
Recent Patents on Cardiovascular Drug Discovery Editorial [Hot Topic: The Medicinal Chemistry of New Agents to Treat Obesity (Guest Editor: Jinhwa Lee)]
Current Topics in Medicinal Chemistry Nutriproteomics – Linking Proteomics Variation with Personalized Nutrition
Current Pharmacogenomics and Personalized Medicine Investigating the Practices of Patients and Hospitals in Treatment of Diabetes - A Survey Questionnaire for Arabic Speaking Countries
Current Diabetes Reviews The Renin-Angiotensin System: New Insight into Old Therapies
Current Medicinal Chemistry Contemporary Risk Assessment and Cardiovascular Outcomes in Peripheral Arterial Disease
Cardiovascular & Hematological Disorders-Drug Targets Transdermal Delivery of Lercanidipine: Microscopic Examination, Rheology and Ex Vivo Permeation Mechanistic Study on Rat Skin by Differential Scanning Calorimetry
Current Nanomedicine Chemistry and Pharmacology of Angiotensin-Converting Enzyme Inhibitors
Current Pharmaceutical Design Reviewing the Cardiovascular Complications of HIV Infection After the Introduction of Highly Active Antiretroviral Therapy
Current Drug Targets - Cardiovascular & Hematological Disorders Inducible Nitric Oxide Synthase as a Possible Target in Hypertension
Current Drug Targets Endothelial Expression of MHC Class II Molecules in Autoimmune Disease
Current Pharmaceutical Design Antimicrobial and Anti-MRSA Effects of Three Extracts of Some Hypericum Species Against Standard Microorganisms and Methicillin Resistant Staphylococcus aureus (MRSA) Strains
Current Bioactive Compounds MicroRNA-mediated MMP Regulation: Current Diagnostic and Therapeutic Strategies for Metabolic Syndrome
Current Gene Therapy Potential Therapeutic Targeting of Platelet-Mediated Cellular Interactions in Atherosclerosis and Inflammation
Current Medicinal Chemistry Ventricular and Vascular Stiffening in Aging and Hypertension
Current Hypertension Reviews Anti-Inflammatory Intervention for Acute Liver Failure: Recent Patents and Future Targets
Recent Patents on Biomarkers Editorial [Hot Topic: Stroke Prevention (Guest Editors: T. Tatlisumak, K. Rantanen and M. Fisher)]
Current Drug Targets Development of Nanocomponent Ointment Composition for the Treatment of Various Etiologies Wounds
Current Nanomedicine Increased Risk of Dementia in Patients with Non-Apnea Sleep Disorder
Current Alzheimer Research