Cu(II) Schiff Base as Catalyst in the Synthesis of 1,8-Dioxodecahydroacridine

Author(s): Seyed Mohammad Vahdat, Hamid Reza Mardani, Hamid Golchoubian, Maryam Khavarpour, Saeed Baghery, Ziba Roshankouhi

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 1 , 2013

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The catalytic property of Cu(II) Schiff-base complex in an efficient synthesis of 1,8-dioxodecahydroacridines was investigated. The one-pot three component reaction of dimedone, aromatic aldehydes and aromatic amines or ammonium acetate in water afforded the corresponding 1,8-dioxodecahydroacridines with excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts at room temperature. The reusability of the catalysts was demonstrated by a five-run test without loss of its activity. Also, this catalyst possesses several advantages including mild reaction conditions, lower catalytic loading, shorter reaction times, high yield of the products, inexpensive and cleaner (Green chemistry) reactions.

Keywords: 1, 8-Dioxodecahydroacridine, Cu(II) Schiff-base catalyst, multi component reaction, one-pot synthesis, water solvent, water, Green chemistry, Acridine, green catalysts, polar solvents.

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Article Details

Year: 2013
Published on: 01 January, 2013
Page: [2 - 6]
Pages: 5
DOI: 10.2174/1386207311316010002

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