Abstract
A flow-based system with solenoid micro-pumps is proposed for fast simvastatin (SMT) determination in pharmaceutical preparations. The method is based on the inhibition of methyl orange bromination in the presence of the analyte with spectrophotometric detection. A linear response was observed between 5.0 and 35 mg L-1 SMT with a detection limit of 1.2 mg L-1 (99.7% confidence level). The coefficient of variation (n = 20) and sampling rate were estimated as 3.3% and 80 determinations per hour, respectively. Reagents consumption was estimated as 3.5 μg of NaBrO3, 9.5 μg of methyl orange and 400 μg of NaBr per determination, generating 4.5 mL of waste. The results for pharmaceutical samples agreed with those obtained by the reference chromatographic procedure at the 95% confidence level. The procedure is a fast, greener and reliable alternative for SMT determination.
Keywords: Simvastatin, Flow analysis, Multicommutation, Multi-pumping, Spectrophotometry, SMT, pharmaceutical, Vascular diseases, chromatographic, Mechanization
Current Pharmaceutical Analysis
Title:A Multi-pumping Flow System for Fast Spectrophotometric Determination of Simvastatin
Volume: 9 Issue: 1
Author(s): Wanessa R. Melchert, Alex D. Batista, Andreia C. Pereira, Diogo L. Rocha and Fabio R.P. Rocha
Affiliation:
Keywords: Simvastatin, Flow analysis, Multicommutation, Multi-pumping, Spectrophotometry, SMT, pharmaceutical, Vascular diseases, chromatographic, Mechanization
Abstract: A flow-based system with solenoid micro-pumps is proposed for fast simvastatin (SMT) determination in pharmaceutical preparations. The method is based on the inhibition of methyl orange bromination in the presence of the analyte with spectrophotometric detection. A linear response was observed between 5.0 and 35 mg L-1 SMT with a detection limit of 1.2 mg L-1 (99.7% confidence level). The coefficient of variation (n = 20) and sampling rate were estimated as 3.3% and 80 determinations per hour, respectively. Reagents consumption was estimated as 3.5 μg of NaBrO3, 9.5 μg of methyl orange and 400 μg of NaBr per determination, generating 4.5 mL of waste. The results for pharmaceutical samples agreed with those obtained by the reference chromatographic procedure at the 95% confidence level. The procedure is a fast, greener and reliable alternative for SMT determination.
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R. Melchert Wanessa, D. Batista Alex, C. Pereira Andreia, L. Rocha Diogo and R.P. Rocha Fabio, A Multi-pumping Flow System for Fast Spectrophotometric Determination of Simvastatin, Current Pharmaceutical Analysis 2013; 9 (1) . https://dx.doi.org/10.2174/1573412911309010015
DOI https://dx.doi.org/10.2174/1573412911309010015 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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