The in vitro generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells from hemangioblast
derived from embryonic stem (ES) or induced pluripotent stem (iPS) cells promises to provide an alternative source of
cells that could replace total bone marrow cells or HSC-enriched fractions. This mini-review deals with innovation related
to hemangioblast-based methods for blood cells production as disclosed in recent patent literature and current barriers to
clinical translation are discussed.
Keywords: Hematopoietic stem cells, hemangioblast-based methods, stem cell technologies
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