Abstract
Migration, proliferation and apoptosis of vascular smooth muscle cells (VSMCs) have recently been identified as important processes in a variety of human vascular diseases, including atherosclerosis, arterial injury, and restenosis after angioplasty. These processes are regulated by interactions between the local cell-cell and cytokine environment. Cytokine induced apoptosis inhibitor (CIAPIN1) is a novel antiapoptotic molecule and plays a vitally important role in malignant phenotypes of cancers. However, the effect of CIAPIN1 on VSMCs has not been reported. In the present study, we constructed the adenovirus encoding CIAPIN1 siRNA and transduced it into VSMCs. The results demonstrated that CIAPIN1 siRNA inhibited proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Our results suggest that CIAPIN1 siRNA might play the key role in VSMC biological function and provide the new therapeutic strategy for vascular diseases.
Current Neurovascular Research
Title:CIAPIN1 siRNA Inhibits Proliferation, Migration and Promotes Apoptosis of VSMCs by Regulating Bcl-2 and Bax
Volume: 10 Issue: 1
Author(s): Zhao Yang, Wei Eric Wang and Qian Zhang
Affiliation:
Keywords: CIAPIN1, siRNA, VSMCs, Apoptosis, Bcl-2, Bax
Abstract: Migration, proliferation and apoptosis of vascular smooth muscle cells (VSMCs) have recently been identified as important processes in a variety of human vascular diseases, including atherosclerosis, arterial injury, and restenosis after angioplasty. These processes are regulated by interactions between the local cell-cell and cytokine environment. Cytokine induced apoptosis inhibitor (CIAPIN1) is a novel antiapoptotic molecule and plays a vitally important role in malignant phenotypes of cancers. However, the effect of CIAPIN1 on VSMCs has not been reported. In the present study, we constructed the adenovirus encoding CIAPIN1 siRNA and transduced it into VSMCs. The results demonstrated that CIAPIN1 siRNA inhibited proliferation, migration and promotes apoptosis of VSMCs by regulating Bcl-2 and Bax. Our results suggest that CIAPIN1 siRNA might play the key role in VSMC biological function and provide the new therapeutic strategy for vascular diseases.
Export Options
About this article
Cite this article as:
Yang Zhao, Eric Wang Wei and Zhang Qian, CIAPIN1 siRNA Inhibits Proliferation, Migration and Promotes Apoptosis of VSMCs by Regulating Bcl-2 and Bax, Current Neurovascular Research 2013; 10 (1) . https://dx.doi.org/10.2174/1567202611310010002
DOI https://dx.doi.org/10.2174/1567202611310010002 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biological Activities of Yarrow Species (Achillea spp.)
Current Pharmaceutical Design Non-Zinc-Binding Inhibitors of MMP-13: GRID-Based Approaches to Rationalize the Binding Process
Current Topics in Medicinal Chemistry Cardiovascular Risk, Inflammation and Physical Activity in Rheumatoid Arthritis
Current Rheumatology Reviews Lipoprotein (a) and Cardiovascular Risk: The Show Must go on
Current Medicinal Chemistry Thromboxane A2 Receptor Blockade Prevents Atherosclerotic Process by its Anti-Inflammatory Effect
Vascular Disease Prevention (Discontinued) Renovascular Hypertension: Lesion Detection, Patient Selection, Treatment Options and Results
Current Hypertension Reviews Does the Immune System Regulate Mood to Defend against Infection? Evidence from Studies of Immune Factors, Depression, and Antidepressants
Current Psychiatry Reviews Genomics and Natural Products: Role of Bioinformatics and Recent Patents
Recent Patents on Biotechnology TNF alpha Inhibition as Treatment Modality for Certain Rheumatologic and Gastrointestinal Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Proteomics Approaches to Understand Linkage Between Alzheimer’s Disease and Type 2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus
Current Topics in Medicinal Chemistry High-Density Lipoprotein at the Interface of Type 2 Diabetes Mellitus And Cardiovascular Disorders
Current Pharmaceutical Design Antioxidant Treatment and Endothelial Dysfunction: Is it Time for Flavonoids?
Recent Patents on Cardiovascular Drug Discovery Regulatory Role of Brg1 and Brm in the Vasculature: From Organogenesis to Stress-Induced Cardiovascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Antihypertensive Effect of Sesamin
Vascular Disease Prevention (Discontinued) Recent Progress in Cerebrovascular Gene Therapy
Current Neurovascular Research Mechanisms And Prevention Of TAVI-Related Cerebrovascular Events
Current Pharmaceutical Design The Polyamine Pathway as a Potential Target for Vascular Diseases: Focus on Restenosis
Current Vascular Pharmacology Therapeutic Development of Interrelated Metabolic and Neurodegenerative Disorders
Current Pharmaceutical Design Neuronal and Vascular Oxidative Stress in Alzheimers Disease
Current Neuropharmacology