Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives

Author(s): Guolong Gu, Haiyan Lin, Yajuan Liu, Liumeng Yang, Yongtang Zheng, Bin Wang, Chunlei Tang, Hai Qian, Wenlong Huang

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 2 , 2013


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Abstract:

A series of Andrographolide derivatives were described and evaluated for their in vitro anti-HIV activity. Compound 11 and 21 showed significant anti-HIV-1 activity in C8166 cells. Since compound 11 had no cytotoxicity, it was expected to be new lead for further development of anti-AIDS agents.

Keywords: Andrographolide, Derivatives, Anti-HIV, C8166 cells, Natural products, Synthesis, Acquired immune deficiency syndrome, human immunodeficiency virus, RDCSY- I capillary apparatus, lymphocyte counts

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2013
Published on: 24 December, 2012
Page: [155 - 163]
Pages: 9
DOI: 10.2174/157018013804725107
Price: $65

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