Novel 2-pyrazolin-1-ylthiazoles as Potential Antimicrobial Agents

Author(s): Bakr Fathy Abdel-Wahab, Ashraf Sediek, Hanan Ahmed Mohamed, Ghada Elsayed Ahmed Awad

Journal Name: Letters in Drug Design & Discovery

Volume 10 , Issue 2 , 2013


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Abstract:

A series of 2-(5-(4-fluorophenyl)-pyrazolin-1-yl)thiazoles prepared as potential antimicrobial agents is described. The synthesis involved the reaction of 5-(4-fluorophenyl)-3-heterocycl-4,5-dihydro-1H-pyrazole-1- carbothioamides 4a,b with various hydrazonoyl chlorides 5 or phenacyl bromides 8-10. These compounds were structurally characterized. The structure of 7 was confirmed by studying the X-ray crystallographic. The antimicrobial evaluations of the newly synthesized products against broad spectrum of bacteria and fungi were performed.

Keywords: Pyrazole, Antimicrobial activity, Hydrazonoyl chlorides, Pyrazoline-1-thioamide, 2-Pyrazoline-1-ylthiazoles, X-ray, JASCO FT/IR-6100, dimethylformamide, Pseudomonas, Candida Albicans

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2013
Published on: 24 December, 2012
Page: [111 - 118]
Pages: 8
DOI: 10.2174/157018013804725143
Price: $65

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