Antibacterial Activity and Structure-activity Relationship Studies of 4- substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Title:Antibacterial Activity and Structure-activity Relationship Studies of 4- substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Volume: 10 Issue: 2

Author(s): Edyta Kusmierz, Agata Siwek, Urszula Kosikowska, Anna Malm, Joanna Stefanska, Katarzyna Dzitko and Monika Wujec

Affiliation:

Keywords: Antimicrobial activity, s-triazole, Structure-activity relationship (SAR) studies, Toxicity, Sigma Aldrich, ampicillin, Gram-positive strains, Klebsiella pneumoniae, humidified environment, Staphylococcus epidermidis

Abstract: Seventeen 4-substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones were synthesized and the structures of the compounds were determined by 1H NMR and IR spectra. In vitro antibacterial potency of all title compounds was evaluated. Additionally, the initial in vitro toxicity screening was performed for one compound using the MTT assay technique. A structure-activity relationship (SAR) studies have been carried out to determine the relevance of the different parameters that define the potency of title s-triazoles.

Cite this article as:

Kusmierz Edyta, Siwek Agata, Kosikowska Urszula, Malm Anna, Stefanska Joanna, Dzitko Katarzyna and Wujec Monika, Antibacterial Activity and Structure-activity Relationship Studies of 4- substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones, Letters in Drug Design & Discovery 2013; 10 (2) . https://dx.doi.org/10.2174/157018013804725198