Seventeen 4-substituted-5-(diphenylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones were synthesized and the
structures of the compounds were determined by 1H NMR and IR spectra. In vitro antibacterial potency of all title
compounds was evaluated. Additionally, the initial in vitro toxicity screening was performed for one compound using the
MTT assay technique. A structure-activity relationship (SAR) studies have been carried out to determine the relevance of
the different parameters that define the potency of title s-triazoles.
Keywords: Antimicrobial activity, s-triazole, Structure-activity relationship (SAR) studies, Toxicity, Sigma Aldrich, ampicillin, Gram-positive strains, Klebsiella pneumoniae, humidified environment, Staphylococcus epidermidis
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