Benzimidazole (benzimidazolone) template certainly deserves the title of “privileged scaffold” in antiviral drug research field
because of the versatility and potential to yield derivatives with a wide range of antiviral activity, such as anti-HIV, anti-HCV, anti-HBV,
anti-HCMV, anti-RSV and anti-rhino/enteroviruses activities, etc. These different biological properties of benzimidazole (benzimidazolone)
derivatives have motivated new studies in searching for novel derivatives with improved activity and also other applications in
pharmaceutical field. No systematic review is available in the literature on the benzimidazole (benzimidazolone) derivatives concerning
the design of potent antiviral inhibitors. Owing to the importance of this heterocyclic system, the aim of this review is to present the main
aspects of exploring antiviral properties, such as the structural modifications, the structure-activity relationship (SAR), making an effort
to highlight the importance and therapeutic potentials of the benzimidazole (one) scaffold in the present antiviral agents.