Animal Models of Carcinogenesis in Inflamed Colorectum: Potential Use in Chemoprevention Study

Author(s): Takuji Tanaka

Journal Name: Current Drug Targets

Volume 13 , Issue 14 , 2012

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Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn’s disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process contribute to multi-stage carcinogenesis of CRC in the inflamed colon. They include alterations in production of reactive oxygen and nitrogen species, upregulation of pro-inflammatory cytokines and inflammatory enzymes, and intestinal immune system. In this short review, experimental animal models of inflammation-associated CRC are described. Also, some preclinical data on chemoprevention of inflammation-associated CRC by astaxanthin and a specific inhibitor of nitric oxide synthase using these inflammation- related -CRC models is briefly introduced.

Keywords: Inflammation and cancer, inflammatory bowel disease, colorectal cancer, chemoprevention, animal model

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Article Details

Year: 2012
Page: [1689 - 1697]
Pages: 9
DOI: 10.2174/138945012804545452
Price: $65

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