Clinical Implication of Meissner’s Corpuscles

Author(s): Jose A. Vega, Alfonso Lopez-Muniz, Marta G. Calavia, Olivia Garcia-Suarez, Juan Cobo, Jesus Otero, Oscar Arias-Carrion, Pablo Perez-Pinera, Manuel Menendez-Gonzalez

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 11 , Issue 7 , 2012

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During the last decade skin biopsy has been confirmed as a tool to provide diagnostic information on some peripheral neuropathies. Most studies were focused on intraepithelial nerve fibers and few studies have investigated large myelinated fibers or whether corpuscles in human skin change quantitatively or qualitatively in pathologies of the peripheral or central nervous system. The main objective of this article is to provide a comprehensive review of Meissner’s corpuscles including their distribution, density and age changes, development, molecular composition, cellular anatomy and physiology. We also describe their involvement in several pathologies and suggest including this dermal structure in the routine study of skin biopsies, looking for changes to be used as potential markers for several disorders. Finally the article draws the main aspects of how to study Meissner’s corpuscles in skin biopsies and gives a view on future perspectives for implementing their use in clinical practice.

Keywords: Meissner’s corpuscles, skin biopsy, neuropathy, guidelines, intraepithelial, myelinated fibers, cellular anatomy, phosphorylated neurofilaments, immunoreactivity, Schwann cells

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Article Details

Year: 2012
Published on: 09 December, 2012
Page: [856 - 868]
Pages: 13
DOI: 10.2174/1871527311201070856
Price: $65

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