2-Imidazolidinones as Chiral Auxiliaries in Asymmetric Synthesis

Author(s): Cuifen Lu, Lei Hu, Guichun Yang, Zuxing Chen.

Journal Name: Current Organic Chemistry

Volume 16 , Issue 23 , 2012

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Chiral 2-imidazolidinones have been exploited with respect to asymmetric alkylation reactions, aldol reactions, Michael addition reactions, etc, and their convenient preparation from many kinds of available materials, greater stability to ring-opening reaction than chiral oxazolidinones and high levels of asymmetric induction make them excellent and show more widely considerable promise as chiral auxiliaries in organic synthesis. In this context, the general construction of chiral 2-imidazolidinones will be presented and the most important applications in the field of organic synthesis will be highlighted.

Keywords: 2-Imidazolidinones, Chiral auxiliaries, Asymmetric synthesis, Asymmetric induction.

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Article Details

Year: 2012
Page: [2802 - 2817]
Pages: 16
DOI: 10.2174/138527212804546895
Price: $58

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