Abstract
We report the use of V, Bi and Bi-V Keggin structure where Mo is partially replaced by V, Bi, and Bi and V, respectively, in the solvent-free multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by the Biginelli method. The incorporation of V, Bi and Bi-V in the structure of PMo notably increases the catalytic activity. The following correlation between the yields of the 3,4- dihydropyrimidin-2-(1H)-ones and the number of acidic sites of the catalysts was observed: PMoBiV > PMoV > PMoBi > PMo. The reaction experiments were performed in the absence of solvent, at 80°C (1 h). Under these conditions and using the most active catalyst (PMoBiV), twelve examples were obtained with very good yields (80%–98%) and high selectivity. The catalyst was easily recycled and reused without appreciable loss of its catalytic activity. The synthetic method presented is a simple, clean and environmentally friendly alternative for the obtention of substituted 3,4-dihydropyrimidin-2-(1H)-ones.
Keywords: 3, 4-Dihydropyrimidin-2-(1H)-ones, Biginelli reaction, Modified keggin heteropolyacids, Solvent-free synthesis.
Current Organic Chemistry
Title:Doped Keggin Heteropolyacids as Catalyst in the Solvent-free, Multicomponent Synthesis of Substituted 3,4-dihydropyrimidin-2-(1H)-ones
Volume: 16 Issue: 23
Author(s): Oriana D’alessandro, Ángel G. Sathicq, Valeria Palermo, Laura. M. Sanchez, Horacio Thomas, Patrcia Vazquez, Thierry Constantieux and Gustavo Romanelli
Affiliation:
Keywords: 3, 4-Dihydropyrimidin-2-(1H)-ones, Biginelli reaction, Modified keggin heteropolyacids, Solvent-free synthesis.
Abstract: We report the use of V, Bi and Bi-V Keggin structure where Mo is partially replaced by V, Bi, and Bi and V, respectively, in the solvent-free multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by the Biginelli method. The incorporation of V, Bi and Bi-V in the structure of PMo notably increases the catalytic activity. The following correlation between the yields of the 3,4- dihydropyrimidin-2-(1H)-ones and the number of acidic sites of the catalysts was observed: PMoBiV > PMoV > PMoBi > PMo. The reaction experiments were performed in the absence of solvent, at 80°C (1 h). Under these conditions and using the most active catalyst (PMoBiV), twelve examples were obtained with very good yields (80%–98%) and high selectivity. The catalyst was easily recycled and reused without appreciable loss of its catalytic activity. The synthetic method presented is a simple, clean and environmentally friendly alternative for the obtention of substituted 3,4-dihydropyrimidin-2-(1H)-ones.
Export Options
About this article
Cite this article as:
D’alessandro Oriana, Sathicq G. Ángel, Palermo Valeria, Sanchez M. Laura., Thomas Horacio, Vazquez Patrcia, Constantieux Thierry and Romanelli Gustavo, Doped Keggin Heteropolyacids as Catalyst in the Solvent-free, Multicomponent Synthesis of Substituted 3,4-dihydropyrimidin-2-(1H)-ones, Current Organic Chemistry 2012; 16 (23) . https://dx.doi.org/10.2174/138527212804546840
DOI https://dx.doi.org/10.2174/138527212804546840 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements