Title:Recent Advances in Medicinal Chemistry of Sulfonamides. Rational Design as Anti-Tumoral, Anti-Bacterial and Anti-Inflammatory Agents
VOLUME: 13 ISSUE: 1
Author(s):Syed Shoaib Ahmad Shah, Gildardo Rivera and Muhammad Ashfaq
Affiliation:Centro de Biotecnologia Genomica, Instituto Politecnico Nacional, Boulevard del Maestro, s/n, Esq. Elías Pina, 88710, Reynosa, Mexico.
Keywords:Anti-bacterial, Anti-inflammatory, Anti-tumoral, Biological activity, Sulfonamide, Structure-activity relationship,
Clinical use
Abstract:Now-a-days, cancer is becoming one of the major problems of public health in the world. Pharmacology
treatment is a way to increase quality and long life. Predominantly, in last decade sulfonamide derivatives have been
described as potential carbonic anhydrase inhibitors. In the present work, we describe recent advances during the last
decade in medicinal chemistry of sulfonamides derivatives with some examples of rational design as anti-tumoral, antibacterial
and anti-inflammatory agents. We show strategy design, structure-activity relationship, biological activity and
advances of new sulfonamide compounds that have more health significance than some clinically used sulfonamides.
