Title:Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and λ-Amino Acids
VOLUME: 19 ISSUE: 36
Author(s):E. Forro and F. Fulop
Affiliation:Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.
Keywords:β-amino acid, λ-amino acid, β-amino ester, burkholderia cepacia lipase PS, candida antarctica lipase B, enantiomer, enzymatic
catalysis, GC enantioseparation, kinetic resolution, β-lactam, λ-lactam, lipase, organic solvent, sequential resolution, solvent-free system,
supercritical CO2.
Abstract:Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β- and λ-amino acids through enzymatic ring
cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO2 medium, and for the enantioselective
hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and
rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.
