Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the most lethal cancers. There is increasing
evidence that cancer stem cells within GBMs, which are often referred to as glioblastoma stem cells (GSCs), play a critical role
in tumor initiation and maintenance. Identification of novel markers for GSCs will lead to better targeting of GSCs which could have
tremendous impact on treatment of GBMs. Cell surface markers are particularly suitable as therapeutic targets. Although several promising
cell surface markers have successfully been used for enrichment of GSCs, their functional roles in maintenance of GSC properties as
well as in GBM formation and development remain to be characterized. In this review, we primarily summarize recent advances in identification
of GSC markers, with a particular focus on cell surface markers.