Antimicrobial Peptides in Oral Cancer: Review Article
Pp. 131-153 (23)
Christina Roebke, Jürgen Harder and Jens E. Meyer
There is increasing evidence that Antimicrobial Peptides (AMPs) are
differentially regulated in cancers such as Oral Squamous Cell Carcinomas (OSCC).
Data showing that AMPs influence the growth of tumor cells, exhibit direct
cytotoxic activity towards cancer cells, function as a tumor suppressor gene or
activate the adaptive immunity suggest that a dysregulation of AMPs may be
associated with the development of cancer. There is no question that, with increasing
resistance against conventional chemotherapy, novel anticancer agents are needed.
It is interesting to speculate that natural AMP or synthetic derivatives can be
used to develop novel strategies to fight cancer diseases and may represent a novel
family of anticancer agents. However, future research is needed to employ the role
of AMPs in cancer and to investigate their role as potential anticancer drugs.
Antimicrobial peptide, defensin, cathelicidin, histatin, adrenomedullin, oral
cancer, immunotherapy, anticancer effect.
Department of Otorhinolaryngology, Head, Neck and Plastic Surgery, Lohmuehlenstr. 5, 20099 Hamburg, Germany.