Abstract
Scientific drug design enables the production of novel agents that may be specific for individual malaria species, particularly by targeting their methods of cellular entry. Though there are practical and theoretical barriers to introducing novel agents into clinical practice, there may also be theoretical benefits to encourage further investigation of such agents, including a reduction in the rate of development of falciparum resistance. This paper discusses the potential risks and benefits such agents using the example of CCR5 blockers, drugs which are already in use for HIV treatment, but may be able to block DARC, the site of Plasmodium vivax into the human red blood cell.
Keywords: DARC, malaria, chemokine receptors, Scientific drug design, novel agents, individual malaria species, theoretical barriers, falciparum resistance, Plasmodium vivax, Plasmodium, human red blood cell, falciparum, thalassemia, antimicrobials, pathogen
Infectious Disorders - Drug Targets
Title:Shooting At the DARC: Potential Issues with Species-Specific Antimalarials
Volume: 12 Issue: 5
Author(s): I. Woolley and K. Horne
Affiliation:
Keywords: DARC, malaria, chemokine receptors, Scientific drug design, novel agents, individual malaria species, theoretical barriers, falciparum resistance, Plasmodium vivax, Plasmodium, human red blood cell, falciparum, thalassemia, antimicrobials, pathogen
Abstract: Scientific drug design enables the production of novel agents that may be specific for individual malaria species, particularly by targeting their methods of cellular entry. Though there are practical and theoretical barriers to introducing novel agents into clinical practice, there may also be theoretical benefits to encourage further investigation of such agents, including a reduction in the rate of development of falciparum resistance. This paper discusses the potential risks and benefits such agents using the example of CCR5 blockers, drugs which are already in use for HIV treatment, but may be able to block DARC, the site of Plasmodium vivax into the human red blood cell.
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Cite this article as:
Woolley I. and Horne K., Shooting At the DARC: Potential Issues with Species-Specific Antimalarials, Infectious Disorders - Drug Targets 2012; 12 (5) . https://dx.doi.org/10.2174/187152612804142189
DOI https://dx.doi.org/10.2174/187152612804142189 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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