Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Synthesis and Surface Modification Techniques for use with MRI and Other Biomedical Applications

Author(s): Serge Yoffe, Tim Leshuk, Perry Everett, Frank Gu

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 3 , 2013

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Superparamagnetic iron oxide nanoparticles (SPIONs) comprise a fundamental technology class within the emerging field of nanomedicine, and have been extensively researched for cancer imaging and therapy. This review article will discuss the chemistry and design considerations associated with the synthesis of SPIONs and their incorporation into pharmaceutical formulations. Specific synthesis methods discussed include coprecipitation, thermal decomposition, microemulsion and solvothermal synthesis, as well as surface treatments and encapsulations to improve the nanoparticle biocompatibility and efficacy. Emerging applications of novel particle designs as MRI contrast agents are also discussed.

Keywords: SPION, magnetite, Fe3O4, colloid, nanoparticle, MRI, PEG, dextran, microemulsion, biocompatibility.

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Article Details

Year: 2013
Page: [493 - 509]
Pages: 17
DOI: 10.2174/1381612811306030493
Price: $65

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PDF: 55