Membrane interacting peptides are reviewed in terms of structure and mode of action on lipid membranes.
Helical, -stranded, peptides containing both helices and strands, cyclic, lipopeptides and short linear peptides are seen to
considerably modulate membrane function. Among peptides that lead to membrane alteration or permeation, antimicrobial
peptides play an important role and some of them may be foreseen as potential new antibiotics. Alternatively, peptides
that do not destroy the membrane are also very important in modulating the structure and dynamics of the lipid bilayer and
play important roles in membrane protein functions. Peptide lipid complexes are shown to be very variable in structure
and dynamics: “carpet”, “barrel stave”, toroid and disordered pores, electrostatic wedge and molecular electroporation
models are discussed. Their assembly is reviewed in terms of electric, amphipathic and dynamic properties of both lipids
Keywords: Helical-, beta-sheet-, cyclic-, linear-peptides, membrane leakage, membrane reinforcement, membrane crossing,
NMR, IR, CD, X-rays, electron microscopy, molecular dynamics.
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Published on: 26 November, 2012
Page: [620 - 631]