Synthesis of Dihydropyridines: Patented Catalysts and Biological Applications

Author(s): Laura M. Sanchez, Angel G. Sathicq, Horacio J. Thomas, Gustavo P. Romanelli

Journal Name: Recent Patents on Catalysis (Discontinued)

Volume 1 , Issue 2 , 2012


The present review focuses on the patented synthetic methods and numerous pharmaceutical applications of 1,4-dihydropyridines. They were originally prepared by the Hantzsch multicomponent reaction, but nowadays there are several new methods. They have improved reaction yield and have reduced the risks of contaminating the environment. These improvements were achieved through the use of different catalytic systems, a variety of reaction solvents, and also some reactions were carried out without either catalyst or reaction solvent.

Keywords: Biological applications, dihydropyridines, Hantzsch reaction, patented catalysts.

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Article Details

Year: 2012
Page: [119 - 128]
Pages: 10
DOI: 10.2174/2211548X11201020119
Price: $65

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