Design, Synthesis and In Vitro Anti-Mycobacterial Activity of Chromene Fused Cytosine and Uracil Analogues

Author(s): Nimesh R. Kamdar, Dhaval D. Haveliwala, Prashant T. Mistry, Saurabh K. Patel

Journal Name: Anti-Infective Agents
Formerly Anti-Infective Agents in Medicinal Chemistry

Volume 11 , Issue 1 , 2013

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A series of chromene fused cytosine and uracil were prepared by the condensation of thiourea or carbon disulphide with 2-amino-7,7-dimethyl-5-oxo-4-(substituted phenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile. The newly synthesized compounds were characterized by IR, 1H-NMR, Elemental analysis and some representative 13C-NMR and Mass spectra. All the title compounds were evaluated for antitubercular and antimicrobial activities against various mycobacterial, bacterial and fungal strains. Some of the compounds have shown promising antimicrobial and antitubercular activity while others were inactive.

Keywords: Antimicrobial activity, antitubercular activity, chromene, fused cytosine, fused uracil.

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Article Details

Year: 2013
Published on: 12 November, 2012
Page: [42 - 48]
Pages: 7
DOI: 10.2174/22113626130105

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PDF: 47