Recent Developments and Prospects for Influenza M2 Ion Channel Inhibitors That Circumvent Amantadine Resistance

Author(s): Petar M. Mitrasinovic

Journal Name: Current Bioinformatics

Volume 7 , Issue 4 , 2012

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Amantadine is a specific anti-influenza a drug that inhibits viral replication by binding to the M2 channel and preventing proton conductance. The increasing resistance to amantadine in strains of the influenza A virus that infect both animals and humans has been highlighted frequently. Resistance is usually caused by one of several single mutations in the M2 channel, but variants with double mutations have also been reported. Attempts to develop alternative inhibitors of the M2 channel that are effective against the resistant mutants have been unsuccessful, mainly because of the lack of information on the precise mode of inhibitor binding. This review summarizes the advances made in determining the mechanisms of action of amantadine and the development of novel inhibitors of the M2 channel during the past 2 years.

Keywords: Amantadine, influenza A virus, inhibitor, M2 ion channel, mutant, resistance, equilibrium, pharmacophore, homotetramer, Xenopus oocytes

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Article Details

Year: 2012
Published on: 11 November, 2012
Page: [366 - 373]
Pages: 8
DOI: 10.2174/157489312803901081
Price: $65

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