An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone
(2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer
(trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.
Keywords: Dithymoquinone, photodimerization, thymoquinone, X-ray structure
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