Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone

Author(s): Alan L. Myers, Yan-Ping Zhang, Mark A. Kramer, William G. Bornmann, Ahmed Kaseb, Peiying Yang and Hai T. Tran

Volume 9, Issue 10, 2012

Page: [762 - 766] Pages: 5

DOI: 10.2174/157017812803901890

Abstract

An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer (trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.

Keywords: Dithymoquinone, photodimerization, thymoquinone, X-ray structure


© 2024 Bentham Science Publishers | Privacy Policy