One-Pot Approach to 4-Vinyl-1,2,3-Triazoles by Cycloaddition of Azides with Propargyl Alcohols Catalyzed by Cu(I)/Ru(III)/TFA

Author(s): Ji Su, Ruimao Hua

Journal Name: Current Organic Synthesis

Volume 9 , Issue 6 , 2012


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Abstract:

An efficient and regioselective one-pot direct synthesis of 4-vinyl-1,2,3-triazoles via cycloaddition of azides with propargyl alcohols and dehydration catalyzed by a CuCl/RuCl3·3H2O bimetallic catalysts in the presence of TFA (Trifluoroacetic acid) is developed.

Keywords: Azides, Cuprous chloride, Propargyl alcohols, Ruthenium trichloride hydrate, 4-Vinyl-1, 2, 3-triazoles, Trifluoroacetic acid.

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [898 - 902]
Pages: 5
DOI: 10.2174/157017912803901646
Price: $65

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