One-pot Synthesis and its Practical Application in Pharmaceutical Industry

Author(s): Wenyi Zhao, Fen-Er Chen

Journal Name: Current Organic Synthesis

Volume 9 , Issue 6 , 2012

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Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.

Keywords: Cascade reaction, multicomponent reaction, one-pot synthesis, tandem reaction, telescoping.

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Article Details

Year: 2012
Page: [873 - 897]
Pages: 25
DOI: 10.2174/157017912803901619
Price: $65

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PDF: 29