Title:Recent Progress on Fucosyltransferase Inhibitors
VOLUME: 12 ISSUE: 14
Author(s):Pedro Merino, Tomas Tejero, Ignacio Delso, Ramon Hurtado-Guerrero, Asier Gomez-SanJuan and David Sadaba
Affiliation:Departamento de Quimica, Instituto de Sintesis Quimica y Catalisis Homogenea (ISQCH), Universidad de Zaragoza-CSIC, Facultad de Ciencias. Edificio D. Planta 3, E-50009 Zaragoza, Spain.
Keywords:Fucosyltransferases, Carbohydrate mimics, Glycoconjugates, Piperidines, Pyrrolidines, C-Glycosides, structure-activity-relationship, polyhydroxylated
Abstract:Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide.
They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial
infections and inflammatory processes, and thus they represent important drug targets for the development of agents for
the treatment of such disorders. This review highlights recent developments regarding carbohydrate mimics as inhibitors
of FucTs. The most recent and relevant synthetic strategies are described.
