Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide.
They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial
infections and inflammatory processes, and thus they represent important drug targets for the development of agents for
the treatment of such disorders. This review highlights recent developments regarding carbohydrate mimics as inhibitors
of FucTs. The most recent and relevant synthetic strategies are described.
Keywords: Fucosyltransferases, Carbohydrate mimics, Glycoconjugates, Piperidines, Pyrrolidines, C-Glycosides, structure-activity-relationship, polyhydroxylated
Rights & PermissionsPrintExport
Published on: 05 November, 2012
Page: [1455 - 1464]