Recent Advances in the Comprehension and the Management of Perioperative Systemic Host Response During Cardiopulmonary Bypass

Author(s): Filip De Somer

Journal Name: Recent Patents on Cardiovascular Drug Discovery
Continued as Recent Advances in Cardiovascular Drug Discovery

Volume 7 , Issue 3 , 2012


Cardiac surgery with cardiopulmonary induces a systemic inflammatory response (SIRS). SIRS is broadly defined as an inflammatory state of the whole body without a proven source of infection. Many pre and postoperative variables have been defined that have a negative impact on SIRS. Although many strategies have been developed, targeting given biomarkers very few of these proved to be effective in a clinical setting. In order to better understand why this happened a new approach for defining SIRS was proposed. This review describes this new concept and the recent patents involved.

Keywords: Cardiopulmonary bypass circuit, coated circuits, ultrafiltration

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Article Details

Year: 2012
Page: [180 - 185]
Pages: 6
DOI: 10.2174/157489012803832865
Price: $65

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