Synthesis of Biologically Active Bridged Diazabicycloheptanes

Author(s): G. Murineddu, B. Asproni, G. Pinna, M.M. Curzu, A. Dore, A. Pau, F. Deligia, G.A. Pinna

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 31 , 2012

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The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

Keywords: 3, 6-diazabicyclo[3.1.1]heptanes, 2, 5-diazabicyclo[2.2.1]heptanes, synthesis, antibacterial activity, antitumor activity, antiinflammatory activity, analgesic activity, antipsychotic activity, ischemic injuries, obesity

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Article Details

Year: 2012
Page: [5342 - 5363]
Pages: 22
DOI: 10.2174/092986712803833317
Price: $65

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