A series of proline-based heterogeneous polymeric organocatalysts was synthesized as monoliths via the
chemo-enzymatic route. These were characterized by various techniques and the one that was synthesized with 1%
crosslinker was used as the candidate catalyst in the three-component one pot reaction, i.e., Mannich-type reaction to synthesize
3-substituted 2,6-diarylpiperidin-4-ones and 4-aryldihydropyrimidinones. The merits of the monolith catalyst, the
mild reaction conditions, simple protocol, and clean reaction makes the synthetic protocol practical and economically attractive.
The catalyst exhibited high efficiency, easy recyclability, reusability and selectivity, especially, with the aromatic
substrates having electron withdrawing substituents which resulted in high conversion.
Keywords: Asymmetric catalysis, Mannich reaction, Organocatalyst, Proline, Polymer catalyst, Reusability, Supported
catalysts, Reusability, Supported catalysts, piperidines, ChemNMR Pro, polarimete, FTIR, Ps values, dihydropyrimidinones, imine, aldehydes
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Published on: 31 October, 2012
Page: [206 - 214]