Abstract
Objective: To investigate nephroprotective potential of Urtica parviflora (UP) against paracetamol (PCM) induced nephrotoxicity in rats.
Methods: Nephrotoxicity was induced in rats by chronic administration of PCM (1 g/kg body weight p.o.) for 21 days. Different doses of UP (250, 500 and 750 mg/kg b.w., p.o.) were administered for 21 days along with PCM. Blood urea, blood urea nitrogen (BUN), serum creatinine, total protein, serum and tissue nitrite, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated. The effect of extract treatment on the renal histopathological profile in PCM nephrotoxic rats was also evaluated.
Results: PCM treatment significantly elevated blood urea, BUN, creatinine, serum nitrite and renal lipid peroxidation along with significant decrement in renal enzymatic and non-enzymatic antioxidants, total proteins while UP treatment significantly attenuated these alterations. The extract was also effective in mitigating renal histopathological changes induced by PCM.
Conclusions: The results suggested potent nephroprotective and antioxidant properties of Urtica parviflora.
Keywords: Urtica parviflora, paracetamol, nephrotoxicity, antioxidant activity, enzymatic, non-enzymatic, lipid, serum, protien, antioxidant.
The Natural Products Journal
Title:Nephroprotective Potential of Urtica parviflora Roxb. Against Paracetamol Induced Nephrotoxicity in Rats
Volume: 2 Issue: 4
Author(s): Savita Pandey, Sangeeta P. Sah and Anita Singh
Affiliation:
Keywords: Urtica parviflora, paracetamol, nephrotoxicity, antioxidant activity, enzymatic, non-enzymatic, lipid, serum, protien, antioxidant.
Abstract: Objective: To investigate nephroprotective potential of Urtica parviflora (UP) against paracetamol (PCM) induced nephrotoxicity in rats.
Methods: Nephrotoxicity was induced in rats by chronic administration of PCM (1 g/kg body weight p.o.) for 21 days. Different doses of UP (250, 500 and 750 mg/kg b.w., p.o.) were administered for 21 days along with PCM. Blood urea, blood urea nitrogen (BUN), serum creatinine, total protein, serum and tissue nitrite, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated. The effect of extract treatment on the renal histopathological profile in PCM nephrotoxic rats was also evaluated.
Results: PCM treatment significantly elevated blood urea, BUN, creatinine, serum nitrite and renal lipid peroxidation along with significant decrement in renal enzymatic and non-enzymatic antioxidants, total proteins while UP treatment significantly attenuated these alterations. The extract was also effective in mitigating renal histopathological changes induced by PCM.
Conclusions: The results suggested potent nephroprotective and antioxidant properties of Urtica parviflora.
Export Options
About this article
Cite this article as:
Pandey Savita, P. Sah Sangeeta and Singh Anita, Nephroprotective Potential of Urtica parviflora Roxb. Against Paracetamol Induced Nephrotoxicity in Rats, The Natural Products Journal 2012; 2 (4) . https://dx.doi.org/10.2174/2210315511202040316
DOI https://dx.doi.org/10.2174/2210315511202040316 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
FoxO3a Governs Early Microglial Proliferation and Employs Mitochondrial Depolarization with Caspase 3, 8, and 9 Cleavage During Oxidant Induced Apoptosis
Current Neurovascular Research Stretch, Shrink, and Shatter the Rhythms: The Intrinsic Circadian Period in Mania and Depression
CNS & Neurological Disorders - Drug Targets Chronic Royal Jelly Administration Induced Antidepressant-Like Effects Through Increased Sirtuin1 and Oxidative Phosphorylation Protein Expression in the Amygdala of Mice
Current Molecular Pharmacology The State of the Art of Pyrazole Derivatives as Monoamine Oxidase Inhibitors and Antidepressant/Anticonvulsant Agents
Current Medicinal Chemistry The Role of Depression, Anxiety and Illness Characteristics on Risky Sexual Behaviour among People Living with HIV in A Malaysian Tertiary Reference Hospital
Current Psychiatry Research and Reviews Invertebrate Models of Dystonia
Current Neuropharmacology 5-Lipoxygenase: A Promising Drug Target Against Inflammatory Diseases-Biochemical and Pharmacological Regulation
Current Drug Targets Subject Index To Volume 6
Central Nervous System Agents in Medicinal Chemistry Nanofibre Based Smart Pharmaceutical Scaffolds for Wound Repair and Regenerations
Current Pharmaceutical Design Heart Rate Variability Indexes in Dementia: A Systematic Review with a Quantitative Analysis
Current Alzheimer Research Assessment of Cytochrome P450 Induction in Human Hepatocytes Using the Cocktail Strategy Plus Liquid Chromatography Tandem Mass Spectrometry
Drug Metabolism Letters Homology-Based Design for Selective GSK-3 Peptide Inhibitors: Patent Applications and Type 2 Diabetes Mellitus
Current Signal Transduction Therapy Proteasome Regulators: Activators and Inhibitors
Current Medicinal Chemistry Targeting of Peripherally Expressed Pain-Related Molecules in Injury- Induced Chronic Neuropathic Pain
CNS & Neurological Disorders - Drug Targets Ribosome Inactivating Proteins (RIPs) from Momordica charantia for Anti Viral Therapy
Current Molecular Medicine Editorial: Forty Five Years and Counting
Adolescent Psychiatry Medication Assisted Treatment of Drug Abuse and Dependence: Global Availability and Utilization
Recent Patents on Anti-Infective Drug Discovery Reducing Rifle Bolt Carrier Bounce
Recent Patents on Mechanical Engineering Inhibitors of Catechol-O-Methyltransferase
CNS & Neurological Disorders - Drug Targets Current and Future Applications of Probiotics
Current Nutrition & Food Science