Halogen Substituents as an Effective Modulators of Antibacterial Activity of Substituted 1,2,4-triazole-3-thiones

Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska, Anna Malm

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 10 , 2012

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Abstract:

Fourteen novel compounds were obtained and their chemical structures were established by 1H-NMR and IR spectra as well as elemental analyses. As one of the most important factors determining the changes of activity of respective fluorophenyl and iodophenyl derivatives, one should consider the volume of halogen substituent and its influence on the lipophilicity of the entire molecule.

Keywords: Aminomethylation, Drug-resistance, Hydroxymethylation, s-triazoles, 1, 2, 4-triazole derivatives, N2-aminomethyl/hydroxymethyl derivative, N4-aryl moiety, Staphylococcus aureus, Elemental analyses, N4-(4-fluorophenyl)

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Article Details

VOLUME: 9
ISSUE: 10
Year: 2012
Page: [947 - 952]
Pages: 6
DOI: 10.2174/1570180811209050947
Price: $65

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