Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles

Author(s): M. Siva Nagi Reddy, B. Sailaja Kumari, B. Hari Babu

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 10 , 2012

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Abstract:

Novel 3,5-disubstituted 1,2,4-oxadiazoles 4a-4j were prepared from commercially available chlorosalicylaldehyde and screened for their cytotoxicity properties using brine shrimp (Artemia salina) bioassay and compared with the standard podophyllotoxin. The oxadiazoles 4a, 4c, 4e and 4h exhibited cytotoxicity activity in the series.

Keywords: 5-chlorosalicylaldehyde, Oxadiazoles, Cytotoxicity, Brine shrimp, Chromene derivatives, Synthesis, tyrosine kinase inhibitors, anti-inflammatory agents, Chromene derivatives, cytotoxicity properties

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Article Details

VOLUME: 9
ISSUE: 10
Year: 2012
Page: [942 - 946]
Pages: 5
DOI: 10.2174/1570180811209050942
Price: $65

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