3-(Adamantan-1-yl)-4-hydroxybenzyl Substituted Purines and Pyrimidines: Synthesis and Cytotoxic Activity

Author(s): Nageswara Rao Kode, Dakshinamurthy Devangachinta, Shashikant Phadtare

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 10 , 2012

Become EABM
Become Reviewer
Call for Editor


Selected adamantanyl purines and pyrimidines 1-10 were synthesized. These compounds were evaluated for cytotoxic activity against NCI-60 DTP human tumor cell line screen. N9-(3'-Adamantan-1-yl)-4'-hydroxy(benzyl)-2- amino-6-chloropurine, 3 and N9-[(3'-(Adamantan-1-yl)-4'-(2'',3'',4''-trifluorobenzyloxy)]benzyl-2-amino-6-chloropurine, 6 elicited significant cytotoxic activity with GI50 values in the 1–10 μM range for selected human tumor cell lines. While other compounds elicited moderate activity with GI50 values in the 10–20 μM range for most human tumor cell lines.

Keywords: Adamantan-1-yl-methylphenol, Cytotoxic activity, 2, 6, 9-substituted purines, 1, 4, 5-substituted pyrimidines, acid-catalyzed Friedel–Crafts alkylation, MEL-TEMP, Clofarabine, 3-adamantan-1-yl-4-hydroxybenzyl, Clofarabine, divergent fluorinated

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Published on: 24 October, 2012
Page: [926 - 933]
Pages: 8
DOI: 10.2174/1570180811209050926
Price: $65

Article Metrics

PDF: 8