New Insights into HLA-G and Inflammatory Diseases

Author(s): Roberta Rizzo, Daria Bortolotti, Olavio R. Baricordi, Enrico Fainardi

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
Formerly Current Drug Targets - Inflammation & Allergy

Volume 11 , Issue 6 , 2012


Human leucocyte antigen-G (HLA-G) is a non-classical HLA class I molecule with an important role at the fetus-maternal interface, preventing fetus recognition and abortion. The role of HLA-G as an immune-modulatory and anti-inflammatory molecule has led to investigate its role in pathological conditions. In these years, HLA-G has been shown to have an important implication in inflammatory pathologies. The focus of this review is to up-date the scientific knowledge on the expression of HLA-G molecules in inflammatory conditions.

Keywords: HLA-G, immunity, immune cells, inflammation, pathology, regulation, Human leucocyte antigen-G, anti-inflammatory, HLA-G typing, Allergic disorders

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Article Details

Year: 2012
Published on: 22 October, 2012
Page: [448 - 463]
Pages: 16
DOI: 10.2174/187152812803590037
Price: $65

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