Novel Antimicrobial Agents Against Multi-drug-resistant Gram-positive Bacteria: An Overview

Author(s): Venetia Giannakaki, Spiros Miyakis

Journal Name: Recent Patents on Anti-Infective Drug Discovery

Volume 7 , Issue 3 , 2012

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Antimicrobial resistance threatens to compromise the treatment of bacterial infectious diseases. Strains resistant to most (if not all) antibiotics available have emerged. Gram-positive such representatives include strains of Methicillinresistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE) and highly-resistant to penicillin Streptococcus pneumoniae. Although the phenomenon of antimicrobial drug resistance is expanding, limited number of new antibiotics has been successfully developed in the last few decades. Several novel antimicrobial agents, however, are currently in diverse phases of development and undergoing clinical trials. This review will summarize the main candidates for novel antibacterial agents active against Gram-positive multi-resistant pathogens along with the discussion of some patents relevant to the topic.

Keywords: Antimicrobials, multidrug resistance, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococcus, penicillin-resistant Streptococcus pneumoniae, clinical trial, Glycopeptide-related Derivatives, Oritavancin, Carbapenems, Fluorocyclines

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Article Details

Year: 2012
Page: [182 - 188]
Pages: 7
DOI: 10.2174/157489112803521959
Price: $58

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