Active Methylene Compounds in the Synthesis of 3-substituted Isobenzofuranones, Isoindolinones and Related Compounds

Author(s): Antonia Di Mola, Laura Palombi, Antonio Massa

Journal Name: Current Organic Chemistry

Volume 16 , Issue 19 , 2012

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Molecules containing 3-substituted isobenzofuranones and isoindolinones skeletons are found in important bioactive compounds and in a number of natural products. As a consequence several synthetic strategies, both asymmetric and non-asymmetric, have been developed. Thus, this review focuses on the main synthetic approaches to obtain these classes of compounds, analysing the common features, the scope and the limitations and at the same time giving particular emphasis to the role of active methylene compounds.

Keywords: Heterocyclic compounds, Bioactive compounds, Active methylene compounds, Tandem reactions, Organocatalysis, Metal catalysts, Aldol reactions, Multi-component reactions, 1, 3-dicarbonyl, hydroxymethylation, formaldehyde

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Article Details

Year: 2012
Page: [2302 - 2320]
Pages: 19
DOI: 10.2174/138527212803520254
Price: $58

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