N-alkyl 2-[(2-oxo-2-aryl ethyl)amino] benzamide derivatives have been synthesized in high yields. This
involves three-component reaction of isatoic anhydride, primary amines in the presence of 2-bromoacethophenone
derivatives. The reaction workup is simple and the products can be easily separated from the reaction mixture.
Keywords: 2-bromoacethophenone, Benzamide, green synthesis, one-pot synthesis, solvent-free, Isatoic Anhydride, Primary Amines, Diversity-oriented synthesis (DOS), heterocycles compound, pharmacological properties
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Published on: 16 October, 2012
Page: [745 - 748]