A Highly Efficient Green Synthesis of N-Alkyl 2-[(2-Oxo-2-Aryl Ethyl) Amino] Benzamide Derivatives from Reaction of Isatoic Anhydride, Primary Amines and 2-Bromoacethophenone

Author(s): Maryam Sabbaghan, Zinatossadat Hossaini

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 9 , 2012

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N-alkyl 2-[(2-oxo-2-aryl ethyl)amino] benzamide derivatives have been synthesized in high yields. This involves three-component reaction of isatoic anhydride, primary amines in the presence of 2-bromoacethophenone derivatives. The reaction workup is simple and the products can be easily separated from the reaction mixture.

Keywords: 2-bromoacethophenone, Benzamide, green synthesis, one-pot synthesis, solvent-free, Isatoic Anhydride, Primary Amines, Diversity-oriented synthesis (DOS), heterocycles compound, pharmacological properties

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Article Details

Year: 2012
Published on: 16 October, 2012
Page: [745 - 748]
Pages: 4
DOI: 10.2174/138620712803519716
Price: $65

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