MT1-MMP Modulates bFGF-Induced VEGF-A Expression in Corneal Fibroblasts

Author(s): Kyu-Yeon Han, Daoud C. Fahd, Makambo Tshionyi, Norma Allemann, Sandeep Jain, Jin-Hong Chang, Dimitri T. Azar

Journal Name: Protein & Peptide Letters

Volume 19 , Issue 12 , 2012


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Abstract:

The cornea is physiologically avascular. Following a corneal injury, wound healing often proceeds without neovascularization (NV); however, corneal NV may be induced during wound healing in certain inflammatory, infectious, degenerative, and traumatic states. Such states disrupt the physiologic balance between pro-angiogenic and antiangiogenic mediators, favoring angiogenesis. Contributors to such states are matrix metalloproteinases (MMPs), which are key factors in both extracellular matrix remodeling and angiogenesis. Similarly, vascular endothelial growth factor A (VEGF-A) and basic fibroblast growth factor (bFGF) exert pro-angiogenic effects. Here, we elaborate on the facilitative role of MMPs—specifically Membrane Type 1 MMP (MT1-MMP, MMP14)—in corneal NV. Additionally, we provide new insight into the signaling relating to MT1-MMP, Ras, and ERK in the bFGF-induced VEGF-A expression pathways within the corneal fibroblasts.

Keywords: Basic FGF, corneal angiogenesis, ERK, MT1-MMP, Ras, VEGF-A, homeostasis, pro-angiogenic effect, Basic fibroblast growth factor (bFGF), vascular endothelial growth factor.

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Article Details

VOLUME: 19
ISSUE: 12
Year: 2012
Published on: 14 October, 2012
Page: [1334 - 1339]
Pages: 6
DOI: 10.2174/092986612803521639
Price: $65

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