Abstract
The cornea is physiologically avascular. Following a corneal injury, wound healing often proceeds without neovascularization (NV); however, corneal NV may be induced during wound healing in certain inflammatory, infectious, degenerative, and traumatic states. Such states disrupt the physiologic balance between pro-angiogenic and antiangiogenic mediators, favoring angiogenesis. Contributors to such states are matrix metalloproteinases (MMPs), which are key factors in both extracellular matrix remodeling and angiogenesis. Similarly, vascular endothelial growth factor A (VEGF-A) and basic fibroblast growth factor (bFGF) exert pro-angiogenic effects. Here, we elaborate on the facilitative role of MMPs—specifically Membrane Type 1 MMP (MT1-MMP, MMP14)—in corneal NV. Additionally, we provide new insight into the signaling relating to MT1-MMP, Ras, and ERK in the bFGF-induced VEGF-A expression pathways within the corneal fibroblasts.
Keywords: Basic FGF, corneal angiogenesis, ERK, MT1-MMP, Ras, VEGF-A, homeostasis, pro-angiogenic effect, Basic fibroblast growth factor (bFGF), vascular endothelial growth factor.
Protein & Peptide Letters
Title:MT1-MMP Modulates bFGF-Induced VEGF-A Expression in Corneal Fibroblasts
Volume: 19 Issue: 12
Author(s): Kyu-Yeon Han, Daoud C. Fahd, Makambo Tshionyi, Norma Allemann, Sandeep Jain, Jin-Hong Chang and Dimitri T. Azar
Affiliation:
Keywords: Basic FGF, corneal angiogenesis, ERK, MT1-MMP, Ras, VEGF-A, homeostasis, pro-angiogenic effect, Basic fibroblast growth factor (bFGF), vascular endothelial growth factor.
Abstract: The cornea is physiologically avascular. Following a corneal injury, wound healing often proceeds without neovascularization (NV); however, corneal NV may be induced during wound healing in certain inflammatory, infectious, degenerative, and traumatic states. Such states disrupt the physiologic balance between pro-angiogenic and antiangiogenic mediators, favoring angiogenesis. Contributors to such states are matrix metalloproteinases (MMPs), which are key factors in both extracellular matrix remodeling and angiogenesis. Similarly, vascular endothelial growth factor A (VEGF-A) and basic fibroblast growth factor (bFGF) exert pro-angiogenic effects. Here, we elaborate on the facilitative role of MMPs—specifically Membrane Type 1 MMP (MT1-MMP, MMP14)—in corneal NV. Additionally, we provide new insight into the signaling relating to MT1-MMP, Ras, and ERK in the bFGF-induced VEGF-A expression pathways within the corneal fibroblasts.
Export Options
About this article
Cite this article as:
Han Kyu-Yeon, C. Fahd Daoud, Tshionyi Makambo, Allemann Norma, Jain Sandeep, Chang Jin-Hong and T. Azar Dimitri, MT1-MMP Modulates bFGF-Induced VEGF-A Expression in Corneal Fibroblasts, Protein & Peptide Letters 2012; 19 (12) . https://dx.doi.org/10.2174/092986612803521639
DOI https://dx.doi.org/10.2174/092986612803521639 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biomolecules as Host Defense Weapons Against Microbial Pathogens
Recent Patents on DNA & Gene Sequences Therapeutic microRNA Delivery Strategies with Special Emphasis on Cancer Therapy and Tumorigenesis: Current Trends and Future Challenges
Current Drug Metabolism Biodistribution and Safety Assessment of Bladder Cancer Specific Recombinant Oncolytic Adenovirus in Subcutaneous Xenografts Tumor Model in Nude Mice
Current Gene Therapy Targeting the Ubiquitin Proteasome System: Beyond Proteasome Inhibition
Current Pharmaceutical Design Caspases: Structure-Guided Design of Drugs to Control Cell Death
Mini-Reviews in Medicinal Chemistry Current View on the Mechanism of Action of Perifosine in Cancer
Anti-Cancer Agents in Medicinal Chemistry Bioactive Peptides from Marine Organisms: A Short Overview
Protein & Peptide Letters Development of Arene Ruthenium Antitumor Complexes
Mini-Reviews in Medicinal Chemistry Essential Role of Gli Proteins in Glioblastoma Multiforme
Current Protein & Peptide Science The Management of Metastatic Bone Disease with the Combination of Bisphosphonates and Radiotherapy: From Theory to Clinical Practice
Anti-Cancer Agents in Medicinal Chemistry Targeting Anti-Cancer Active Compounds: Affinity-Based Chromatographic Assays
Current Pharmaceutical Design Natural Products As Antimitotic Agents
Current Topics in Medicinal Chemistry Multiple Protective Functions of Sigma1 Receptor
Current Protein & Peptide Science Hepatocyte Growth Factor and Macrophage-stimulating Protein “Hinge” Analogs to Treat Pancreatic Cancer
Current Cancer Drug Targets Preclinical Evaluation of a Monoclonal Antibody (3C6) Specific for Prostate-Specific Membrane Antigen
Current Radiopharmaceuticals Imidazoles and Benzimidazoles as Tubulin-Modulators for Anti-Cancer Therapy
Current Medicinal Chemistry Immunotherapy for Prostate Cancer
Current Pharmaceutical Design Protein Microarrays: Technological Aspects, Applications and Intellectual Property
Recent Patents on Biotechnology RAN GTPase as a Target for Cancer Therapy: Ran Binding Proteins
Current Molecular Medicine Electroporation Gene Therapy: New Developments In Vivo and In Vitro
Current Gene Therapy