An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

Ling-ling, Zhao; Yu, Wan; Hai-ying, Wang; Chao, Wang; Xiao-xiao, Zhang; Shu-ying, Huang; Gui-xiang, Liu; Liang-feng, Chen; Hui, Wu

An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

Author(s): Ling-ling Zhao, Yu Wan, Hai-ying Wang, Chao Wang, Xiao-xiao Zhang, Shu-ying Huang, Gui-xiang Liu, Liang-feng Chen, Hui Wu

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Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 9 , 2012

DOI : 10.2174/157017812803521144

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Abstract:

Chain 1,3-dicarbonyl compounds were firstly used as starting material to react with 5-amino-3-methyl-1- phenylpyrazol and aromatic aldehydes to prepare 1H-pyrazolo[3,4-b]pyridines in basic ionic liquid [bmim]OH. The onestep three-component reaction is simple and efficient. Additionally, water was the only one by-product during the whole process.

Keywords: Basic ionic liquid, pyrazolo[3, 4-b]pyridines, infertility, addiction, symptoms, inhibitors, three-component reaction, pKa, steric hindrance, recrystallized

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Letters in Organic Chemistry

Title:An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

VOLUME: 9 ISSUE: 9

Author(s):Ling-ling Zhao, Yu Wan, Hai-ying Wang, Chao Wang, Xiao-xiao Zhang, Shu-ying Huang, Gui-xiang Liu, Liang-feng Chen and Hui Wu

Affiliation:School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou, 221116, P. R. China.

Keywords:Basic ionic liquid, pyrazolo[3, 4-b]pyridines, infertility, addiction, symptoms, inhibitors, three-component reaction, pKa, steric hindrance, recrystallized

Abstract:Chain 1,3-dicarbonyl compounds were firstly used as starting material to react with 5-amino-3-methyl-1- phenylpyrazol and aromatic aldehydes to prepare 1H-pyrazolo[3,4-b]pyridines in basic ionic liquid [bmim]OH. The onestep three-component reaction is simple and efficient. Additionally, water was the only one by-product during the whole process.

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Ling-ling Zhao, Yu Wan, Hai-ying Wang, Chao Wang, Xiao-xiao Zhang, Shu-ying Huang, Gui-xiang Liu, Liang-feng Chen and Hui Wu, “An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH”, Letters in Organic Chemistry (2012) 9: 671. https://doi.org/10.2174/157017812803521144

DOI https://doi.org/10.2174/157017812803521144	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255

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VOLUME: 9
ISSUE: 9
Year: 2012

Published on: 14 October, 2012

Page: [671 - 676]
Pages: 6
DOI: 10.2174/157017812803521144
Price: $65

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